Yan (a chemist with Discovery Partners International, Inc.) presents 17 papers on methods of purification and analysis that can ensure that combinatorial libraries are "synthesizable," purifiable," and "drugable." Approaches for monitoring reactions on solid support and reaction optimization for library synthesizing NMR analysis and other methods occupy opening chapters. High-throughput analysis of combinatorial library qualities is discussed before explorations of various high-throughput purification techniques are presented. Finally, analytical methods used in postsynthesis and postpurification are described. Annotation 2004 Book News, Inc., Portland, OR (booknews.com)