This Handbook is a key reference on the intergration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchs studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminats. Prev. ed.: 2001.