Over the last few decades, biology, psychology, anthropology, and cognate fields have substantially enriched traditional philosophical theories about who we are and where we come from. Nevertheless, the hallowed topic of human nature remains frustratingly elusive. Why have we not been able to crack the mystery? Marco J. Nathan provides an overview and explanation of recent research and argues that human nature is a core scientific concept that is not susceptible to an explanation, scientific or otherwise. He traces the scientific history of human nature to conclude that, as an epistemological indicator, science cannot adequately grasp human nature without dissolving it in the process.