This Handbook brings together a collection of seminal research on the Sustainable Development Goals (SDGs) and investigates the effectiveness of the 17 goals in achieving transformative change towards sustainable development. As a collection of inter- and transdisciplinary research from around the world, this volume explores the applications, implications, and best practices of the goals at thematic, regional, and national levels, providing specific examples from a diverse range of places such as Australia, Brazil, China, DRC, India, Italy, the Sahel region of Africa, and USA among others.