Chapters delve into specific applications of big data and AI including mobility, tourism, and land use, drawing on case studies from diverse urban environments across Europe and North America. Expert authors evaluate future opportunities for leveraging these technologies, addressing the integration of machine learning into spatial econometric models, the use of self-organizing maps to study demographic shifts, and novel approaches to simulating contagion patterns during pandemics. Ultimately, the Handbook emphasizes the potential of AI to contribute to social good.