Presenting a new framework to understand the work of artists such as Lee Bontecou, Franklin Williams, Nancy Grossman, Mel Casas, Yayoi Kusama, Jim Nutt, John Outterbridge, Ralph Arnold, H. C. Westermann, Romare Bearden, Louise Bourgeois, Christina Ramberg, and Robert Arneson, this study features an expansive chronology that highlights how a broad group of artists across the United States connected to each other through exhibitions, galleries, and collectives, offering a fresh perspective on how artists in the 1960s harnessed psychoanalysis, wordplay, and assemblage, among other strategies, to create new horizons for subject matter and form that continue to reverberate in American art today.