This book concentrates on applied and computational aspects of statistics, focusing on conceptual understanding and Python-based calculations. Based on years of experience teaching introductory and intermediate Statistics courses at Touro University and Brooklyn College, this book compiles multiple aspects of applied statistics, teaching the reader useful skills in statistics and computational science with a focus on conceptual understanding. This book does not require previous experience with statistics and Python, explaining the basic concepts before developing them into more advanced methods from scratch.