Penned by seasoned microbiologists Ferric C. Fang and Arturo Casadevall, this book offers a comprehensive analysis of the scientific enterprise through various lenses, including historical, philosophical, and personal. From their unique vantage points as researchers, clinicians, and educators, Fang and Casadevall dissect the intricate mechanisms of science, shedding light on its strengths and weaknesses. Through engaging historical anecdotes, personal narratives, and insightful academic studies, they present a candid evaluation of science's performance, including a thought-provoking examination of its role during the COVID-19 pandemic.